All our DNA testing is carried out by
Genetic Technologies Australia.
DNA Testing of my dogs has begun and will be ongoing. We test for the PRCD
PRA gene as well as DNA profiling of each dog.
Although I have found one carrier, I can now make an informed decision
regarding her breeding, and if bred to a clear male she can never
produce affected offspring, insuring that no affected pups will ever be
produced by this kennel.
progeny in turn will be tested to determine if pups are Clear or
New and prospective crested owners, to
help you understand the importance of health testing in our breed and to
learn about Progressive Retinal Atrophy-Progressive Rod Cone
Degeneration (PRA-PRCD) and how to eliminate it from our breed, go to
Genetic Technologies Limited
GTG Genetics where our PRA-PRCD tests
are processed. Also read below for more information. Our results are all
Although a little expensive at first, once
foundation lines have been tested, the only testing there after is to
DNA type offspring from clear parents to confirm parentage, or test
litters where a carrier is one of the parents to determine the status of
the pups. This means that you will not have the huge on going expense of
testing every individual for the disease.
With the discovery of the marker for PRA-PRCD,
we can now, with a simple cheek swab, test our breeding stock to easily
prevent ever breeding affected puppies. Our aim is to eliminate the
gene from our breeding program entirely.
Here at Mohawk and at our sister kennels,
Hibay, Liliah, Blackheath, Auscrest, Caddarra and Chinaroad we are not
only testing our current breeding stock we have started with our
veterans to not only clear current lines but to clear our entire kennel
as far back as possible.
More kennels are now joining the DNA
testing movement. With new public awareness and now government demand,
why should you accept anything less?
For puppy enquiries
we are more than happy to answer your questions, if unable to help you
with a pup at anytime, we can supply you a list of other kennels within
Australia and New Zealand that are testing their dogs for PRA-PRCD.
The OptiGen prcd-PRA
The OptiGen prcd-PRA test is a
DNA-based test that helps you avoid one form of Progressive Retinal
Atrophy (PRA). PRA refers to a group of diseases that cause the retina
of the eye to degenerate slowly over time. The result is declining
vision and eventual blindness. “prcd” stands for “progressive
rod-cone degeneration” which is the type of PRA known in several breeds.
The gene mutation causing the prcd form of
PRA is present in the Chinese Crested breed. Some dogs carry the
mutation and some PRA affected Chinese Cresteds have the prcd
form of PRA as detected by DNA testing.
More than one form
The prcd gene is the cause of some,
but not most, cases of PRA in Chinese Crested tested so far. There
appears to be at least two different genetic forms of PRA in this
breed, even though the clinical signs of PRA in all diseased dogs look
similar. At this point, one form cannot be distinguished from another
based on an eye exam. This is significant – a Chinese Crested that is
Normal/Clear for prcd-PRA could still be at risk for having or
carrying another form of PRA.
The exact frequency of prcd-PRA
compared to other types of PRA in the Chinese Crested breed is not
known. We do know that prcd-PRA carriers are not uncommon, but
prcd-PRA does NOT appear to be the predominant disease type. More
information on its frequency will be gathered as more dogs are tested.
should be tested for prcd-PRA:
Any Crested can be tested for its prcd-PRA
status. It is most sensible to test any dogs that are related to or in
line with a known prcd-PRA affected or prcd carrier dog.
Due to this relationship, they are at risk for inheriting the prcd
While annual eye exams by veterinary
ophthalmologists are recommended for all breeds, regardless of genetic
testing results, this is especially important for Cresteds since there
is more than one form of PRA known to affect the breed.